Oxford and AstraZeneca decided to go on a different route to deliver vaccines to patients, and it is through an intranasal shot to administer the protection without using needles. However, its clinical trial phase for the nasal COVID-19 vaccine was a letdown for the company, as it did not achieve the results they wish to attain with the new shot.
The researchers will focus on redeveloping the vaccine for its future availability, furthering the previous shots that inject it into arms.
Oxford, AstraZeneca's Nasal COVID Vaccine is a Flop
(Photo : CDC on Unsplash)
The researchers published their findings in the clinical trials of the latest Nasal COVID-19 vaccine from Oxford and AstraZeneca via the eBioMedicine journal. However, these are not the results that the researchers hoped for, as the vaccines failed to deliver the protection it aims to bring to recipients with nasal administration.
The nasal vaccine was not able to develop antibodies for its control groups, with 42 people participating in the University of Oxford's clinical trials.
The team administered the nasal COVID vaccine to 30 unvaccinated individuals, those who did not have any prior shots to protect them against the virus, and 12 people who were previously vaccinated.
Both control group did not achieve the needed results in this formulation.
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Will the Companies Still Develop the Nasal Vaccine?
According to Ars Technica, the good news here is that the nasal vaccine did not generate any harmful side effects to its recipients. Oxford and AstraZeneca's intramuscular formulation was also used in the tests, using the same formula for its nasal administration of the vaccine.
The researchers need to redevelop and improve their vaccine to make it work, something which puts them back on the drawing board to deliver the shot.
COVID-19 Vaccines
Many pharmaceutical companies in the world centered on delivering vaccines for all and centered on different concoctions and formulas to protect against the viral virus of 2020. Two of the leading companies in vaccine development were Pfizer & BioNTech and Moderna's mRNA-based shots which were the most effective among all.
On the other hand, companies like Oxford & AstraZeneca, Johnson&Johnson's, and others developed their vaccines traditionally using the adenovirus material. AstraZeneca's vaccine is the next in effectivity rate, with Jansen's single-dose COVID-19 vaccine also centering on an acceptable percentage for its vaccine.
Nevertheless, getting either the mRNA or adenovirus shots from these manufacturers is effective in protecting against the virus.
Oxford and AstraZeneca aim to present a new shot that does not require needles, but users need to take it through their noses and have the liquid enter through their sinus passage to be absorbed by the body. It is not effective when using the same formulation as its intramuscular shot, but the company aims to develop it for soon distribution for all.
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Written by Isaiah Richard
