DNA mutation is currently important to solve cancer and skin health issues. And now, some scientists were able to develop a new method called NanoSeq (nanorate sequencing) to detect DNA changes in any human tissue.
Marina Kemelman, Research Associate at the AIDS Vaccine Design and Development Laboratory, collects bacteria transfected with DNA as part of research at the laboratory's campus in the former Brooklyn Army Terminal December 1, 2008 in New York City. The laboratory, seeking a vaccine to prevent the spread of AIDS, is part of the International AIDS Vaccine Initiative (or IAVI), a global not-for-profit, public-private partnership working to accelerate the development of a vaccine to prevent HIV infection and AIDS. December 1 is the 20th annual World AIDS Day around the world.
This medical innovation was created by the Wellcome Sanger Institute. They claimed that NanoSeq can make it possible to study how genetic mutations happen within human tissues. Researchers also said that it could have unprecedented accuracy.
The new study called "Somatic mutation landscapes at single-molecule resolution" was published by The Nature Journal.
"Somatic mutations drive the development of cancer and may contribute to aging and other diseases," explained the involved researchers. "Despite their importance, the difficulty of detecting mutations that are only present in single cells or small clones has limited our knowledge of somatic mutagenesis to a minority of tissues."
How NanoSeq Method Works
According to Clinical Omics' latest report, the new NanoSeq method is extremely accurate. It allows the detection of new mutations in non-dividing cells.
Blood samples taken from volunteers are labelled and ready to be stored in the UK Biobank which will hold up to 15 million urine and blood samples, all controlled by robotics on April 17, 2007, Stockport, England. The new UK Biobank is the largest blood based research project in the world. The research project will involve 500,000 people across the UK and follow their health for next 30 years or more providing a resource for scientists battling diseases.
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This is currently a great medical innovation since the traditional methods and other techniques are having a hard time detecting DNA changes in non-dividing cells.
On the other hand, Technology Networks also reported that the new NanoSeq technique can also study samples of colon, blood, brain, and muscle. Thanks to this capability, the researchers now claim that the idea of cell division in the main mechanism driving genetic also changes.
How Did NanoSeq's Developers Create it?
The involved researchers explained that they improved an advanced a sequencing method called duplex sequencing 1. During the study, the experts also searched for errors in duplex sequence data.
Thanks to their efforts, they were able to identify the somatic mutations are concentrated at the ends of DNA fragments. Aside from these, they also discovered some major flaws in the previous duplex sequencing 1 method.
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Written by: Griffin Davis
